8) The most commonly occurring conjugention reaction for drugs and their metabolites is a) Glucuronidation b)Acetylation c) Methylation d) Glutathione conjugation

The correct answer is a) Glucuronidation.Glucuronidation is the most commonly occurring conjugation reaction for drugs and their metabolites. It involves the conjugation of a drug or its metabolite with glucuronic acid, which is a process catalyzed by UDP-glucuronosyltransferase (UGT) enzymes. This reaction increases the water solubility of the drug or metabolite, facilitating its excretion from the body through the bile or urine.