morning of adviciantie effect on the enzymes activation. 5. The nerve gas Sarin the organophosphorus compound, was used in a terrorist attack in Japanese subway. Sarin is the inhibitor of acetylcholinesterase Nausea,coma, convulsions , respiratory apanese and death have resulted from the use of this gas by people. a) write down the reaction catalyzed by acetylcholinesterase: b) specify the mechanism of inhibition of the reaction by Sarin; c) explain the difference in action of Sarin and proserin which is used as drug in atony of intestine and myasthenia.

a) The reaction catalyzed by acetylcholinesterase is the hydrolysis of acetylcholine to produce choline and acetic acid. The reaction can be represented as:<br /><br />Acetylcholine + H2O → Choline + Acetic acid<br /><br />b) Sarin is an organophosphorus compound that acts as an inhibitor of acetylcholinesterase. The mechanism of inhibition involves the formation of a covalent bond between the phosphorus atom of Sarin and the serine residue of the active site of acetylcholinesterase. This prevents the enzyme from catalyzing the hydrolysis of acetylcholine, leading to an accumulation of acetylcholine in the synaptic cleft. The excessive acetylcholine causes overstimulation of the muscles, resulting in symptoms such as nausea, coma, convulsions, respiratory failure, and death.<br /><br />c) Sarin and Proserin both inhibit acetylcholinesterase, but they have different effects on the body. Sarin is a potent nerve gas that causes severe symptoms and is often used in terrorist attacks. Proserin, on the other hand, is a drug used to treat atony of the intestine and myasthenia. It works by increasing the availability of acetylcholine at the neuromuscular junction, which helps to improve muscle tone and strength.