The UNESCO Universal Declaration om Bioethics and Human Rights The basic principles of bioethics and Human Rights Article 7 -Persons without the capacity to consent In accordance with domestic law , special protection is to be given to persons who do not have the capacity to consent: a. authorization for research and medical practice should be obtained in accordance with the best interest of the person concerned and in accordance with domestic law .However , the person concerned should be involved to the greatest extent possible in the decision -making process of consent,as well as that of withdrawing consent; b .research should only be carried out for his or her direct health benefit, subject to the authorization and the protective conditions prescribed by law and if there is no research alternative of comparable effectiveness with research participants able to consent.Research which does not have potential direct health benefit should only be undertaken by way of exception . with the utmost restraint, exposing the person only to a minimal risk and minimal burden and,if the research is expected to contribute to the health benefit of other persons in the same category , subject to the conditions prescribed by law and compatible with the protection of the individual's human rights . Refusal of such persons to take part in research should be respected. on .How and for what should authorization be carried out? 02 .How should research be conducted with people who have limited or no opportunity to agree?