2 Disassociation of oxidation and phosphorylation Endogenous and exogenous uncouplers.Mechanism of Inhibitors of tissue respiration complexes.Oxygen toxicity . Active forms of oxygen . Mechanism of their formation.Mechanism of cell membrane damage Antioxidants.

Oxidation and phosphorylation are two important processes that occur in cells. Oxidation refers to the loss of electrons from a molecule, while phosphorylation refers to the addition of a phosphate group to a molecule. These two processes are closely linked and are essential for the production of energy in cells.<br /><br />Disassociation of oxidation and phosphorylation can occur due to the presence of certain substances called uncouplers. Uncouplers are molecules that can disrupt the normal flow of electrons in the electron transport chain, which is the process that links oxidation and phosphorylation. There are two types of uncouplers: endogenous and exogenous. Endogenous uncouplers are naturally occurring substances in the body, while exogenous uncouplers are substances that are introduced into the body from the outside, such as drugs or toxins.<br /><br />Inhibitors of tissue respiration complexes are molecules that can block the activity of certain enzymes involved in the electron transport chain. This can disrupt the normal flow of electrons and lead to a decrease in the production of energy in cells.<br /><br />Oxygen toxicity refers to the harmful effects of oxygen on cells and tissues. Oxygen is essential for life, but it can also be toxic in certain situations. Active forms of oxygen, such as reactive oxygen species (ROS), can cause damage to cells and tissues. ROS are formed as a byproduct of the normal metabolic processes in cells and can cause damage to DNA, proteins, and lipids.<br /><br />Antioxidants are molecules that can neutralize ROS and prevent them from causing damage to cells and tissues. They are important for maintaining the health and function of cells and are found in many foods, such as fruits and vegetables.