20 . When LDL interacts with its receptor?(specify one or more answers) after a decrease in free cholestero I content after TAG accumulation after modification of apoB- 100 after a decrease in phospholipid content after accumulation of cholesterol lesters

When LDL interacts with its receptor, the following events occur:<br /><br />1. **After modification of apoB**: The LDL particle undergoes receptor-mediated endocytosis. The LDL receptor binds to the LDL particle, which has apoB-100 (a protein component of the LDL particle) on its surface. This binding facilitates the internalization of the LDL particle into the cell.<br /><br />2. **After accumulation of cholesterol esters**: Once inside the cell, the LDL particle is transported to the lysosome, where it is broken down. The cholesterol esters from the LDL particle are then transported to the endoplasmic reticulum, where they are hydrolyzed to free cholesterol. This free cholesterol can then be used for various cellular processes or stored in lipid droplets.<br /><br />The other options listed (after a decrease in free cholesterol content, after TAG accumulation, after a decrease in phospholipid content) are not directly related to the interaction between LDL and its receptor.