8) The most commonly occurring conjugention reaction for drugs and their metabolites is a) Glucuronidation b)Acetylation c) Methylation d) Glutathione conjugation

The correct answer is a) Glucuronidation.<br /><br />Glucuronidation is the most commonly occurring conjugation reaction for drugs and their metabolites. It involves the conjugation of a drug or its metabolite with glucuronic acid, which is a process catalyzed by UDP-glucuronosyltransferase (UGT) enzymes. This reaction increases the water solubility of the drug or metabolite, facilitating its excretion from the body through the bile or urine.