- 4. Phosphofructokinase (E_(3)) is the regulatory enzyme of glucose catabolism. This pathway produces ATP. If the concentration of ATP is high the synthesis of Fru-1,6-P is decreased. 1) What class of enzyme does phosphofructok inase belong to ? 2) What type of regulation has this enzyme? Describe the properties of such type of regulation. 3) Name the metabolites of this pathway which bind to the active and regulatory sites of the enzyme.
- 3. Trypsin catalyzes the degradatation of proteins: -met-ser-tyr-lys-glu-ala-. __ -met-ser-tyr-lys + glu-ala- __ Optimum of enzyme action -pH=7,8,t^circ =37^circ This enzyme is secreted by pancreas as zymogen - trypsinogen. 1) Specify the class of the enzyme. Name and explain the mechanism of this enzyme activation.. 2) Draw the plot and explain the effect of substrate concentration on the reaction velocity. Give the definition of Km. 3) Show effect of pH=3 on enzyme activity and explain it.
- 2. It is known hemoglobinopathies, which arise due to mutations in one of histidines a-or beta - chains binding with the iron in the heme group These mutations stabilize the iron in Fe^3+ form.Some drugs (eg. sulfonamides) or chemicals (eg. anilin) also can cause methemoglobinemia . Suggest, how change the properties of Hb in these cases For this: 1) Describe the structure and function of Hb A as a transport protein. 2) Explain the role of iror ions in active centers of Hb for the binding of O_(2) 3) How many molecules of O_(2) can bind mutant Hb if mutation occurs in alpha - subunits? 4) Why can ascorbic acid be used to treat of such patients.
- 5. Hammenr, nocne HaxoxzeHua Ha BbITHCaH HOMOã C yanymemmen cocrosmis IIpn yxoze H3 cramronapa HOKYMeHT BbmHCKa H3 CTâTIHOHapHoro 60.ThHOTO (c) yKa3aHHeM marroza H Ha3HaYeHHeM Jeqerrisi . Harrent ocrance He HOBOHEH H norpe6osan BbUJaTb Ha pyKH CaNTy MexputuHHCKyio Kapry MOTHEMPOBAB TEM, "TOO HaHHbII LOKYMeHT ero 3,TopoBbe, a 3Ha"THT Takoke Kapra HeO6xozzHNa exty, ADN TOTO 9TOGBL 3HaTE CBOII JINaTHO3 KakHe pa3bscHentrs namenry? Ilozprexar III ero npocb6a yzoB.TeTBopeHHKO?
- 5. Myasthenia ( muscle weakness ) is characterized by damage in the transmission of neurotic impulse and decreased amount of acetyleholine due to autoimmune mechanisms. Prozerine is used for treatment of this disease.Specify the mechanism of this drug action. For this: 1) Write the reaction of acceptebolin.: degradation at neuromuscular junction. 2) What enzyme will be inhibited with prozerine? Name the class of this enzyme. 3) What is the mechanism of this enzyme inhibition?
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